(R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine

(R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine - Names and Identifiers

Name	1-Pyrrolidinecarboxylic acid, 2-[(methoxymethylamino)carbonyl]-,1,1-dimethylethyl ester, (2R)-
Synonyms	(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine (R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine 1-Pyrrolidinecarboxylic acid, 2-[(methoxymethylamino)carbony... (R)-tert-butyl 2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] (R)-tert-butyl 2-(N-Methoxy-N-MethylcarbaMoyl)pyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 2-[(methoxymethylamino)carbonyl]-,1,1-dimethylethyl ester, (2R)- 1-Pyrrolidinecarboxylic acid, 2-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester, (2R)-
CAS	288086-98-6

(R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine - Physico-chemical Properties

Molecular Formula	C12H22N2O4
Molar Mass	258.31

(R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine - Introduction

acid, 2-[(methoxymethylamino)carbonyl]-,1,1-dimethylethyl ester, (2R)-Chemical formula c14h253o4, is an organic compound.

Nature:
-Appearance: Colorless to yellowish crystal or powdery solid.
-Melting point: About 60-62 ° C.
-Solubility: Soluble in ethanol, dichloromethane and acetonitrile, insoluble in water.

Use:
The compound is widely used as a nitrogen protecting reagent in organic synthesis. It is commonly used as a temporary protecting group in amino acid synthesis and polypeptide synthesis to inhibit the bypass reaction of amino acids or polypeptides to achieve the purpose of selective synthesis of desired compounds.

Method:
acid, 2-[(methoxymethylamino)carbonyl]-,1,1-dimethylethyl ester, (2R)-can be synthesized by the following steps:
1. Methyl N-methoxypyrrolidine formamide is reacted with di-tert-butyl dicarbonate to obtain 1-tert-butoxycarbene.
2. By a stereoselective substitution reaction, 1-tert-butoxycarbene and asymmetric 1-methylphenylethanone were reacted to give benzoxyl, 2-[(methoymethylamino) carbonyl]-,1,1-dimethylethyl ester, (2R)-.

Safety Information:
When using the fluoric acid, 2-[(methoxymethylamino)carbonyl]-,1, 1-dimethyleyl ester, (2R)-, it is necessary to follow appropriate safety operation procedures, wear protective glasses and gloves. It may cause irritation and damage to the eyes, skin and respiratory tract, so contact should be avoided. When handling the compound, make sure to operate in a well-ventilated laboratory environment and use protective equipment to protect yourself.

Last Update：2024-04-10 22:29:15